Sex Hormone Binding Globulin (SHGB) is a protein produced in the liver; it binds to the hormone testosterone, oestradiol and dihydrotestosterone (DHT). When SHBG is in its bound state with testosterone it is considered biologically inactive.
Approximately 50-65% of testosterone is bound to SHBG with only approximately 2-3% consisting of free testosterone and the remainder being loosely bound to albumin (the primary blood protein).
Changes in the amount of SHBG can affect the amount of hormone that is available.
SHBG is commonly tested to evaluate low testosterone (androgen deficiency) in males; and is also used to assess androgen excess in females. This should be tested when there are signs and symptoms that indicate an increase or decrease in testosterone or if total testosterone is inconsistent with the patient's signs and symptoms.
A blood specimen is required, which can be taken at any time of the day. Your practitioner may recommend when in your cycle the sample should be collected. Fasting is not required.
Once the practitioner has given the patient their request form, the patient takes it to their nearest Australian Clinical Labs collection centre. If you are unsure of your nearest collection centre head to location on our website or call us on 1300 554 480 between 9.00am and 5.00pm Monday to Friday for details.
Turnaround time is usually 7-10 working days.
Patients does not need to fast or make any special preparation before having blood collected.
Patient results are delivered to the referring practitioner via electronic download unless requested otherwise. Results can also be issued via hardcopy, fax or web based e-viewer.