Intestinal Permeability (IP)

The Intestinal Permeability (IP) test, also referred to as a “leaky gut” test, is a precise and non-invasive method for assessing gastrointestinal mucosal integrity. Damage to the lining of the gastrointestinal tract (small and large intestine) is common in people with conditions such as food sensitivity and food allergy, irritable bowel syndrome, Crohn’s disease, arthritis, coeliac disease and dermatological conditions such as eczema, psoriasis and acne.

The lining of the gut wall is often subjected to a wide variety of insults from substances such as alcohol, caffeine, spices, medicines and environmental chemicals. The impact of chronic stress may also affect the permeability of the gut wall over time. Correcting the altered permeability may have an immediate effect on the relief of symptoms and facilitate the gradual improvement in the underlying condition.

The IP is a challenge test using Lactulose and Mannitol – Note: neither of these sugars contains lactose.

Test Kit

After the practitioner has provided a request form, the patient can order their Intestinal Permeability kit online at Each test kit contains full instructions.

Specimen Requirements:

Urine Sample - Home testing kit

One urine specimen taken from a six hour urine collection.

This test kits provided contain everything required to complete the test.

Patient Preparation

  • Patients must fast from 10pm the evening before the urine specimen is collected (water may be consumed during this time).
  • Completely empty the bladder before starting urine collection.
  • Avoid all foods and drinks containing fructose, all analgesics and Non-Steroidal Anti-inflammatory Drugs (NSAIDs) during the 6 hour collection as these may interfere with the results.
  • Do not collect urine during menstruation.
  • Drink one (1) glass only of water or other fluids during test period.


This test kit is also suitable for children between the ages on 4-12 years.
Mannitol and Lactulose solution dosage must be halved for patients 12 years old and under.

Turnaround Time

The standard turnaround time for this test is 10-14 business days.



Additional $20.00 postage & handling fee applies to this test.


Prepayment is required when order test kit.



Companion Tests:

  • Complete Digestive Stool Analysis (CDSA)
  • MyDNA

The results of the IP test may be further supported by additional Australian Clinical Labs Functional Pathology tests. Poor digestive function may contribute to altered gut permeability and be responsible for further damage to the lining of the gastrointestinal tract. The Complete Digestive Stool Analysis (CDSA) provides practitioners with additional information on the many causes of altered gut function and its consequences

MyDNA liver test may also be a useful test to address the potential implications of altered intestinal permeability.
Increased permeability may exacerbate high Phase I activity in the liver which in turn increases permeability.
Therefore, combining the MyDNA with the IP test will provide a comprehensive overview of the important role the liver may play in terms of efficiency of detoxification and its impact on the health of the lining of the gastrointestinal tract.